Tricarboxylic acids and derivatives
Medchemexpress LLC 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | 99.4% | 1 G
Fmoc-NH-PEG6-CH2COOH is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It also functions as a PEG-based PROTAC linker, applicable in the synthesis of PROTACs. This compound facilitates the controlled degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system.
- Cleavable linker for ADC synthesis
- PEG-based PROTAC linker
- Utilizes ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Molecular weight of 561.62
- Formula C29H39NO10
- Appearance: colorless to light yellow liquid
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC Triammonium phosphate trihydrate | 25447-33-0 | MFCD00151223 | ≥98.0% | 203.13 | H18N3O7P | 500g
Triammonium phosphate trihydrate interacts with the magnesium ions to form a precipitate which can be used for magnesium separation from lithium in salt-lake brines[1]
Medchemexpress LLC Oxeladin citrate | 52432-72-1 | 98.0% | 1 ML
Oxeladin citrate is an orally active and brain-penetrant cough suppressant. It acts as a selective sigma 1 receptor agonist with a Ki of 25 nM, and has potential applications in pulmonary diseases and stroke research.
- Orally active and brain-penetrant cough suppressant
- Selective sigma 1 receptor agonist
- Used for pulmonary diseases and stroke research
- Facilitates S1R mediated brain-derived neurotrophic factor secretion
- Reduces infarct expansion in subacute phase of stroke
- Improves neurological function
Medchemexpress LLC Butamirate citrate | 18109-81-4 | MFCD00315222 | 99.9% | 499.6 g/mol | C24H37NO10 | 5 MG
Butamirate citrate is an orally active antitussive research compound supplied as the citrate salt. It acts centrally to suppress cough and has reported bronchodilatory and anti-inflammatory effects. Provided as a high-purity analytical standard for research use only.
- Orally active antitussive agent suitable for research.
- High purity analytical standard for assay and method development.
- Reported bronchodilatory and anti-inflammatory properties.
- Available in small packaged quantities for laboratory use.
- For research use only; not for human or clinical use.
Medchemexpress LLC Azido-PEG6-CH2COOH | 880129-82-8 | ≥98.0% | 365.38 | 5 G
Azido-PEG6-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Suitable for synthesizing PROTACs
- Click chemistry reagent due to azide group
- Enables CuAAc reactions
- Participates in SPAAC reactions with DBCO or BCN groups
Sigma Aldrich Fine Chemicals Biosciences Trisodium citrate dihydrate meets USP testing specifications | 6132-04-3 | MFCD00150031 | 5kg
Trisodium citrate dihydrate meets USP testing specificationsPurity: | MW: 294.1 | 6132-04-3 | MFCD00150031 | 5kg
Apexbio Technology LLC Orphenadrine Citrate 4682-36-4 10mM (in 1mL DMSO)
Orphenadrine Citrate (CAS 4682-36-4) is a small molecule utilized in biomedical research for its pharmacological modulation of neurological pathways It acts by inhibiting the binding of [ 3H]MK-801 to the phencyclidine (PCP) site of the N-methyl-D-aspartate (NMDA) receptor in human frontal cortex tissue implicating antagonism at NMDA-type glutamate receptors Orphenadrine has historically served as an antiparkinsonian antispastic and analgesic agent Its ability to modulate NMDA receptor activity makes it a valuable tool for studies investigating glutamatergic neurotransmission and related neuropharmacological mechanisms
Medchemexpress LLC 5,8,11,14,17,20-hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | MFCD26142983 | 99.4% | 561.62 g/mol | C29H39NO10 | 50 MG
Fmoc-NH-PEG6-CH2COOH is an Fmoc-protected PEG6 linker bearing a terminal carboxylic acid and an Fmoc-protected amine. It is used as a hydrophilic spacer in the synthesis of proteolysis targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs), providing solubility and a reactive handle for amide coupling.
- Fmoc-protected amine for orthogonal protection in synthesis.
- Terminal carboxylic acid suitable for amide coupling.
- PEG6 spacer increases hydrophilicity and solubility.
- High reported purity (≈99.4%).
- Available in multiple package sizes for milligram to gram scale work.
Apexbio Technology LLC Citrate-Synthase-Act-Assay-Kit
Citrate Synthase Activity Assay Kit is a crucial tool in biochemical and pharmaceutical research primarily used to measure the enzymatic activity of citrate synthase an essential enzyme in the citric acid cycle Originating from cellular metabolism studies it aids in understanding the conversion of oxaloacetate and acetyl-CoA to citrate and CoA-SH This reaction plays a pivotal role in energy production and metabolic regulation The kit is commonly used in in vitro assays with activity detectable in nanomolar to low micromolar ranges Applications include use in cellular models animal studies and drug screening to analyze metabolic pathways and potential drug interactions Experimental concentrations typically depend on the specific research design Its precision and reliability make it indispensable for academics and industry professionals investigating metabolic disorders cancer metabolism and mitochondrial function
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 500 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets the protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Targets PROTAC linkers within the PROTAC pathway
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC Triammonium phosphate trihydrate | 25447-33-0 | MFCD00151223 | ≥98.0% | 203.13 | H18N3O7P | 1kg
Triammonium phosphate trihydrate interacts with the magnesium ions to form a precipitate which can be used for magnesium separation from lithium in salt-lake brines[1]