Tricarboxylic acids and derivatives
eMolecules Zinc citrate dihydrate | 546-46-3 | | 5g
Combi-Blocks, Inc. | Zinc citrate dihydrate | 5g | 603131897 | QF-5462 | 95.000 | 546-46-3 | | 610.370 | C12H14O16Zn3
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Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | MFCD32693867 | 98.0% | 321.06 g/mol | C6H7NNa3O8P | 5 MG
Sparfosic acid trisodium (CAS 70962-66-2) is a research-grade DNA antimetabolite that potently inhibits aspartate transcarbamoyl transferase (ATCase). Supplied as the trisodium salt, it is used in biochemical and cell-based studies to probe pyrimidine biosynthesis and to assess synergistic cytotoxic effects in combination with chemotherapeutic agents.
- Potent ATCase inhibitor for studying pyrimidine biosynthesis.
- 98.0% purity suitable for research applications.
- Supplied as the trisodium salt in solid powder form.
- Available in small pack sizes (5 mg-100 mg) and as 10 mM in DMSO solution.
- Molecular weight 321.06 g/mol; formula C6H7NNa3O8P.
- Useful in cell-based assays to evaluate synergy with chemotherapeutics.
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 250 MG
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
Apexbio Technology LLC Lithium Citrate 6080-58-6 500g
Lithium Citrate is a lithium-based compound widely utilized in biomedical research due to its ability to modulate mood stability and neuronal signaling Studies indicate that Lithium Citrate influences numerous biochemical pathways including enzyme inhibition and neurotransmitter regulation contributing to mood stabilization effects seen in bipolar disorder (BD) models Experimentally Lithium Citrate has shown capability in reducing self-injurious behaviors and addressing acute manic episodes in BD research models Additionally it facilitates the dissolution of uric acid crystals proposing potential relevance in gout-associated investigations Lithium Citrate also displays inhibitory properties towards prostatic acid phosphatase (PAP) a mechanism behind some observed side effects Currently detailed IC50 data for Lithium Citrate s enzyme inhibition effects remain limited in literature
Medchemexpress LLC 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | 99.4% | 1 G
Fmoc-NH-PEG6-CH2COOH is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It also functions as a PEG-based PROTAC linker, applicable in the synthesis of PROTACs. This compound facilitates the controlled degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system.
- Cleavable linker for ADC synthesis
- PEG-based PROTAC linker
- Utilizes ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Molecular weight of 561.62
- Formula C29H39NO10
- Appearance: colorless to light yellow liquid
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 500 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets the protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Targets PROTAC linkers within the PROTAC pathway
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC Bragsin1 | 369631-68-5 | 99.9% | 273.16 | 10 MG
Bragsin1 is a potent, selective, and noncompetitive inhibitor of the ArfGEF BRAG2, which inhibits Arf GTPase activation with an IC50 of 3 μM. It functions as a noncompetitive interfacial inhibitor by binding to the PH domain of BRAG2 and does not affect the Sec7 domain of human ArfGEFs. Bragsin1 also exhibits anti-cancer activity.
- Potent, selective, and noncompetitive inhibitor of ArfGEF BRAG2.
- Inhibits Arf GTPase activation with an IC50 of 3 μM.
- Binds to the PH domain of BRAG2.
- No effect on the Sec7 domain of human ArfGEFs.
- Exhibits anti-cancer activity.
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | 50 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs feature two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to a specific target protein. This mechanism allows PROTACs to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Leverages ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Electron Microscopy Sciences Ammonium Water 0.3% 500 ML
Used in Ehrlich's Hematoxylin , Mallory (1938); Ehrlich (1886), Nuclei.
Medchemexpress LLC Triammonium phosphate trihydrate | 25447-33-0 | MFCD00151223 | ≥98.0% | 203.13 | H18N3O7P | 100g
Triammonium phosphate trihydrate interacts with the magnesium ions to form a precipitate which can be used for magnesium separation from lithium in salt-lake brines[1]
Medchemexpress LLC CH2COOH-PEG6-CH2COOH 250mg
CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC HO-PEG-CH2COOH | 10,000 Da | HO-(CH2CH2O)n-CH2COOH | 1 G
HO-PEG-CH2COOH (MW 10,000) is a linear polyethylene glycol polymer terminated with a hydroxyl group and a carboxymethyl (-CH2COOH) group. Supplied as a solid for research use, it is intended as a PEG linker or building block for conjugation chemistries such as PROTAC synthesis and PEGylation.
- Molecular weight 10,000 Da, providing spacer length for linker design.
- Hydroxyl and carboxylic acid terminal groups for orthogonal functionalization.
- Water-soluble polymeric structure suitable for bioconjugation and linker applications.
- Supplied as a solid with recommended storage at -20°C under inert atmosphere.
- Available in small research quantities for method development and synthesis.
- Documentation includes datasheet, COA, and SDS for handling and characterization.